Advocate Spot-On Dog, Monthly Spot-On Protection from Fleas, Heartworm & Worms Treatment for Extra Large Dogs Over 25 kg. Advocate Spot-On is an easy to apply monthly treatment offering comprehensive parasite protection. Reinfesting fleas stop biting in 3-5 minutes and are killed within 1 hour. Larval flea stages are killed in the dog's surroundings. Advocate Spot-On also treats and controls lice, mange, and ear mites, & reduces the incidence of flea allergy dermatitis. Advocate Spot-On prevents heartworm disease and treats and controls adult & juvenile stages of roundworms and hookworms. Advocate Spot-On protects dogs from new worm infestations between treatments, kills whipworm and aids in the prevention of flea tapeworm. Advocate Spot-On is the only product that protects against the deadly oesophageal worm. Safe for use on puppies from 7 weeks of age and any weight.