Advocate Dog, Monthly Spot-On Protection from Fleas, Heartworm & Worms, Three Pack Flea Treatment for Large Dogs 10 - 25 kg. Advocate is an easy to apply monthly spot-on treatment offering comprehensive parasite protection. Reinfesting fleas stop biting in 3-5 minutes and are killed within 1 hour. Larval flea stages are killed in the dog's surroundings. Advocate also treats and controls lice, mange, and ear mites, & reduces the incidence of flea allergy dermatitis. Advocate prevents heartworm disease and treats and controls adult & juvenile stages of roundworms and hookworms. Advocate protects dogs from new worm infestations between treatments, kills whipworm and aids in the prevention of flea tapeworm. Advocate is the only product that protects against the deadly oesophageal worm. Safe for use on puppies from 7 weeks of age and any weight.