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Updated 2 Oct 2026

What’s the best parasite prevention for cats? A comparison guide for cat flea, tick, and worm protection

Parasites may be small, but the trouble they cause for your cat can be anything but. Regular protection helps keep fleas, ticks and worms off your cat and reduces the risk from parasites that can also affect people.

There is no single product that suits every cat or covers every parasite. This guide compares common options of parasite protection for cats available in Australia, including what they cover, how often they are used and important points to discuss with your vet.

All-in-one flea, tick and worm protection for cats

Broad-spectrum all-in-one products cover several internal and external parasites in one regular dose. They are often called “all in one” protection, but that does not mean every parasite of concern to cats is covered: protection differs by product. Some cats may need an additional compatible wormer or tick-control product incorporated into their parasite protection regime to cover the gaps.

Compare all-in-one flea, tick and worm products

Advocate

BRAVECTO®
Plus

NexGard
Spectra

Revolution

Revolution
Plus

Application

Spot-on

Spot-on

Spot-on

Spot-on

Spot-on

Frequency

Monthly

Every 2 months

Monthly

Monthly

Monthly

Fleas

✔

✔

✔

✔

✔

Flea larvae
& pupae in
environment

✔

✘

✘

✔

✔

Ticks

✘

✔

✔

✘

✔

Repels ticks

✘

✘

✘

✘

✘

Ear mites

✔

✔

✔

✔

✔

Feline mange mites

✔

✘

✔

✘

✔

Lice

✔

✘

✘

✔

✔

Heartworm

✔

✔

✔

✔

✔

Lungworm

✔

✔

✔

✘

✘

Roundworms

✔

✔

✔

✔

✔

Hookworms

✔

✔

✔

✔

✔

Tapeworms

✘

✘

✔

✘

✘

Advocate

Application: Spot-on.

Frequency: Monthly.

Minimum age: From 9 weeks of age.

Safe for pregnant & lactating cats? Not approved for use.

Weight ranges: Kittens and Small Cats up to 4 kg; Cats over 4 kg.

Active ingredients: Imidacloprid and moxidectin.

Parasites Advocate protects against

  • Fleas

  • Flea larvae & pupae in the surrounding environment

  • Ear mites

  • Feline mange mites

  • Lice

  • Heartworm

  • Lungworm

  • Roundworms

  • Hookworms

  • Transmission of flea tapeworm through protection against fleas

Parasites not covered by Advocate

  • Ticks

  • Tapeworms

BRAVECTO® Plus

Application: Spot-on.

Frequency: Every 2 months for flea and paralysis tick protection, or every 3 months for flea protection only.

Minimum age and weight: From 9 weeks of age and 1.2 kg.

Safe for pregnant & lactating cats? Safety has not been established.

Weight ranges: Small 1.2-2.8 kg; Medium over 2.8-6.25 kg; Large over 6.25-12.5 kg.

Active ingredients: Fluralaner and moxidectin.

Other considerations:

  • For cats over 12.5 kg, use an appropriate combination of pipettes for their weight, as directed on the label.

Parasites BRAVECTO® Plus protects against

  • Fleas

  • Ticks

  • Ear mites

  • Heartworm

  • Lungworm

  • Roundworms

  • Hookworms

  • Transmission of flea tapeworm through protection against fleas

Parasites not covered by BRAVECTO® Plus

  • Flea larvae & pupae in the surrounding environment

  • Feline mange mites

  • Lice

  • Tapeworms

NexGard Spectra Spot-on for Cats

Application: Spot-on.

Frequency: Monthly.

Minimum age and weight: From 8 weeks of age and 0.8 kg.

Safe for pregnant & lactating cats? Approved for use.

Weight ranges: Small 0.8-2.4 kg; Medium and Large 2.5-7.5 kg.

Active ingredients: Praziquantel, esafoxolaner and eprinomectin.

Other considerations:

  • For cats over 7.5 kg, use an appropriate combination of pipettes for their weight, as directed on the label.

Parasites NexGard Spectra Spot-on for Cats protects against

  • Fleas

  • Ticks

  • Ear mites

  • Feline mange mites

  • Heartworm

  • Lungworm

  • Roundworms

  • Hookworms

  • Tapeworms

Parasites not covered by NexGard Spectra Spot-on for Cats

  • Flea larvae & pupae in the surrounding environment

  • Lice

Revolution

Application: Spot-on.

Frequency: Monthly.

Minimum age: From 6 weeks of age.

Safe for pregnant & lactating cats? Approved for use.

Weight ranges: Puppies and Kittens up to 2.5 kg; Cats 2.6-7.5 kg.

Active ingredients: Selamectin.

Other considerations:

  • Keep your cat dry for at least two hours after application.

Parasites Revolution protects against

  • Fleas

  • Flea eggs, larvae & pupae in the surrounding environment

  • Ear mites

  • Lice

  • Heartworm

  • Roundworms

  • Hookworms

  • Transmission of flea tapeworm through protection against fleas

Parasites not covered by Revolution

  • Ticks

  • Feline mange mites

  • Lungworm

  • Tapeworms

Revolution Plus

Application: Spot-on.

Frequency: Monthly.

Minimum age and weight: From 8 weeks of age and 1.25 kg.

Safe for pregnant & lactating cats? Safety has not been established.

Weight ranges: Kitten 1.25-2.5 kg; Medium 2.6-5 kg; Large 5.1-10 kg.

Active ingredients: Selamectin and sarolaner.

Other considerations:

  • Fast drying – dries within 4 hours.

  • For cats over 10 kg, use an appropriate combination of tubes for their weight, as directed on the label.

Parasites Revolution Plus protects against

  • Fleas

  • Flea eggs, larvae & pupae in the surrounding environment

  • Ticks

  • Ear mites

  • Feline mange mites

  • Lice

  • Heartworm

  • Roundworms

  • Hookworms

  • Transmission of flea tapeworm through protection against fleas

Parasites not covered by Revolution Plus

  • Lungworm

  • Tapeworms

Cat flea and tick protection

Fleas can leave cats itchy and turn the home into a breeding ground, while ticks can cause serious illness. The paralysis tick is of particular concern in Australia. The right protection depends on where your cat lives or travels.

Compare cat flea and tick products

BRAVECTO®

Frontline Spray

Seresto

Application

Spot-on

Spray

Collar

Frequency

Every 3 months

3 or 8 weeks

8 months

Fleas

✔

✔

✔

Flea larvae & pupae
in environment

✘

✘

✔

Ticks

✔

✔

✔

Repels ticks

✘

✘

✔

Ear mites

✔

✘

✘

Feline mange mites

✘

✘

✘

Lice

✘

✔

✘

BRAVECTO® Spot-on for Cats

Application: Spot-on.

Frequency: Every 3 months.

Minimum age and weight: From 9 weeks of age and 1.2 kg.

Safe for pregnant & lactating cats? Safety has not been established.

Weight ranges: Small 1.2-2.8 kg; Medium over 2.8-6.25 kg; Large over 6.25-12.5 kg.

Active ingredients: Fluralaner.

Other considerations:

  • For cats over 12.5 kg, use an appropriate combination of pipettes for their weight, as directed on the label.

Parasites BRAVECTO® Spot-on for Cats protects against

  • Fleas

  • Ticks

  • Ear mites

  • Transmission of flea tapeworm through protection against fleas

Parasites not covered by BRAVECTO® Spot-on for Cats

  • Flea larvae & pupae in the surrounding environment

  • Feline mange mites

  • Lice

  • Heartworm

  • Lungworm

  • Intestinal worms

Frontline Spray

Application: Spray.

Frequency: Every 3 weeks for paralysis ticks protection or every 8 weeks for fleas.

Minimum age: From 2 days of age.

Safe for pregnant & lactating cats? Safety has not been established.

Formats: Available in several bottle sizes; dosing is based on the number of pumps per kilogram (see product label).

Active ingredients: Fipronil.

Other considerations:

  • Toxic to rabbits.

  • Flammable. Keep animals away from open flames and heat sources until the coat is dry.

Parasites Frontline Spray protects against

  • Fleas

  • Ticks

  • Lice

Parasites not covered by Frontline Spray

  • Flea larvae & pupae in the surrounding environment

  • Ear mites

  • Feline mange mites

  • Heartworm

  • Lungworm

  • Intestinal worms

Seresto for Kittens & Cats

Application: Collar.

Frequency: Up to 8 months.

Minimum age: From 10 weeks of age.

Safe for pregnant & lactating cats? Safety has not been established.

Size: One adjustable collar.

Active ingredients: Imidacloprid and flumethrin.

Other considerations:

  • Repels ticks, helping reduce the risk of tick-borne disease.

Parasites Seresto for Kittens & Cats protects against

  • Fleas

  • Flea larvae & pupae in the surrounding environment

  • Ticks

Parasites not covered by Seresto for Kittens & Cats

  • Ear mites

  • Feline mange mites

  • Lice

  • Heartworm

  • Lungworm

  • Intestinal worms

Cat wormers

Wormers generally target intestinal worms such as roundworms, hookworms, whipworm and tapeworms, and some may also protect against heartworm. Cats can pick up intestinal worms through contaminated soil, prey and fleas, so worming is one piece of protection worth keeping on schedule.

These wormers do not cover fleas, ticks, or other external parasites and are best used alongside other parasite protection as part of a broader prevention plan.

Different tapeworms species may require particular active ingredients or more frequent treatment. If you see worms despite regular treatment, or your cat remains unwell, book a vet consultation rather than giving an extra dose.

Compare cat wormers

Drontal

Milbemax

ParaGard

Profender

Application

Tablet

Tablet

Tablet

Spot-on

Frequency*

Every 3 months

Monthly or every 3 months

Every 3 months

Every 3 months

Heartworm

✘

If given monthly

✘

✘

Lungworm

✘

✘

✘

✔

Roundworms

✔

✔

✔

✔

Hookworms

✔

✔

✔

✔

Tapeworms

✔

✔

✔

✔

Giardia

Under vet direction

✘

✘

✘

*The schedule shown is for adult cats. Kittens need more frequent intestinal worming, and cats with particular exposure risks may need to follow a different schedule.

Drontal for Cats

Application: Tablet.

Frequency: Depends on age and exposure risk.

  • Adults: Every 3 months. In hydatid tapeworms areas, every 6 weeks.

  • Kittens: Fortnightly from 6-12 weeks of age, then monthly until 6 months of age. After 6 months, as per adult schedule.

  • For Giardia: Requires more frequent dosing. Use as instructed by your veterinarian.

Minimum age: From 6 weeks of age.

Safe for pregnant & lactating cats? Approved for use.

Weight ranges: Cats up to 4 kg; Large Cats over 4 kg.

Active ingredients: Praziquantel and pyrantel.

Parasites Drontal protects against

  • Roundworms

  • Hookworms

  • Tapeworms

Parasites not covered by Drontal

  • Heartworm

  • Lungworm

  • Fleas

  • Ticks

  • Mites

  • Lice

Milbemax for Cats

Application: Beef-flavoured tablet.

Frequency: Depends on age and whether the product is also being used for heartworm prevention.

  • Adults: Every 3 months for intestinal worms only, or monthly when also used for heartworm prevention.

  • Kittens: At 6, 8 and 12 weeks of age and then every 3 months.

Minimum age and weight: From 6 weeks of age and 0.5 kg.

Safe for pregnant & lactating cats? Approved for use.

Weight ranges: Kittens and Small Cats 0.5-2 kg; Medium and Large Cats over 2-8 kg.

Active ingredients: Milbemycin oxime and praziquantel.

Other considerations:

  • Can be given with or without food

Parasites Milbemax protects against

  • Heartworm when given monthly

  • Roundworms

  • Hookworms

  • Tapeworms

Parasites not covered by Milbemax

  • Heartworm, if only used ever 3 months

  • Lungworm

  • Fleas

  • Ticks

  • Ear mites

  • Feline mange mites

  • Lice

ParaGard for Cats

Application: Liver-flavoured tablet.

Frequency: Depends on age and exposure risk.

  • Adult: Every 3 months.

  • Kittens: Treat according to weight at 2, 4, 8 and 12 weeks of age – thereafter every 3 months.

  • Breeding Queens: Treat during the mating period, during the gestation period, one week before birth and 3-4 weeks after birth.

Minimum age: From 2 weeks of age.

Safe for pregnant & lactating cats? Studies have not been conducted in pregnant queens and therefore use of the product in those animals should be carefully considered.

Format: One tablet size; dose according to body weight.

Active ingredients: Praziquantel and oxibendazole.

Parasites ParaGard protects against

  • Roundworms

  • Hookworms

  • Tapeworms

Parasites not covered by ParaGard

  • Heartworm

  • Lungworm

  • Fleas

  • Ticks

  • Mites

  • Lice

Profender

Application: Spot-on.

Frequency: Every 3 months.

Minimum age: From 8 weeks of age.

Safe for pregnant & lactating cats? Approved for use.

Weight ranges: Medium Cats 2.5-5 kg; Large Cats over 5-8 kg.

Active ingredients: Emodepside and praziquantel.

Parasites Profender protects against

  • Lungworm

  • Roundworms

  • Hookworms

  • Tapeworms

Parasites not covered by Profender

  • Heartworm

  • Fleas

  • Ticks

  • Mites

  • Lice

Cat flea control

Flea-control products can be useful when other parasites are covered separately or when recommended by your vet for an active flea problem that needs targeted treatment.

Compare cat flea-control products

Advantage

Capstar

Frontline Plus

Application

Spot-on

Tablet

Spot-on

Frequency

Monthly

One-off treatment

Monthly

Duration of effect

Long-acting

Short-acting

Long-acting

Fleas

✔

✔

✔

Flea larvae & pupae
in environment

✔

✘

✔

Lice

✘

✘

✔

Advantage for Cats

Application: Spot-on.

Frequency: Monthly.

Minimum age: From birth.

Safe for pregnant & lactating cats? Approved for use.

Weight ranges: Small Cats and Kittens up to 4 kg; Cats over 4 kg.

Active ingredients: Imidacloprid.

Parasites Advantage for Cats protects against

  • Fleas

  • Flea larvae & pupae in the surrounding environment

  • Transmission of flea tapeworm through protection against fleas

Parasites not covered by Advantage for Cats

  • Ticks

  • Mites

  • Lice

  • Heartworm

  • Lungworm

  • Intestinal worms

Capstar

Application: Tablet.

Frequency: One-off dose for adult fleas on the cat at time of treatment. It does not provide ongoing protection and should be followed by a longer-lasting flea protection product, as well as implementing appropriate environmental flea control measures. Follow the label if another dose is needed.

Minimum age and weight: From 4 weeks of age and 0.5 kg.

Safe for pregnant & lactating cats? Approved for use.

Weight range: Small Dogs and Cats 0.5-11 kg.

Active ingredient: Nitenpyram.

Other considerations:

  • Kills adult fleas for 24 hours only and does not provide ongoing protection.

  • Can be given with or without food.

Parasites Capstar protects against

  • Adult fleas for 24 hours only

Parasites not covered by Capstar

  • Flea larvae & pupae in the surrounding environment

  • Ticks

  • Mites

  • Lice

  • Heartworm

  • Lungworm

  • Intestinal worms

Frontline Plus

Application: Spot-on.

Frequency: Monthly.

Minimum age: From 8 weeks of age.

Safe for pregnant & lactating cats? Approved for use.

Weight ranges: One size, no minimum or maximum weight labelled.

Active ingredients: Fipronil and (S)-methoprene.

Other considerations:

  • Toxic to rabbits.

Parasites Frontline Plus for Cats protects against

  • Fleas

  • Flea larvae, pupae, and other life stages in the surrounding environment

  • Lice

  • Transmission of flea tapeworm through protection against fleas

Parasites not covered by Frontline Plus for Cats

  • Ticks

  • Mites

  • Heartworm

  • Lungworm

  • Intestinal worms

On a yellow background,  a flea, tick, and worm prepare to eat dinner. On the left are the words "Take your pet off the menu. Protect your pet from fleas, ticks, and worms."

Keep your cat off the menu with regular flea, tick and worm protection

The right parasite protection for your cat is one you can give consistently and that covers the risks for your cat's age, weight, health, lifestyle and location.

Not sure which products are best for your pet? Your local Petbarn and Greencross Vets team members can help you understand which combination of products can help protect your pet.

Frequently asked questions about cat parasite protection

Yes, indoor cats need regular parasite protection. Indoor living reduces some exposure but does not remove it. Fleas can enter on people or other pets, mosquitoes can get indoors and worm eggs may be carried inside on shoes or soil. Keep your cat's protection current according to the label and your vet's advice.

Some cat parasites can affect people. Fleas may bite humans, while some intestinal worms can spread through contaminated soil or faeces, or through accidental ingestion of an infected flea. Regular parasite control, prompt litter-box cleaning and good hand hygiene help reduce the risk.

Yes. Australia's generally mild climate means fleas, ticks, mosquitoes and worms can remain a risk across the year. Continue your cat's parasite protection through the cooler months unless your vet recommends a different schedule.

There is no proven natural remedy that safely and reliably clears all common cat parasites. Use products registered for cats and follow the label. If you suspect an infestation, ask your vet which treatment is appropriate.

Yes, but take sensible hygiene precautions until your cat has been treated. Avoid contact with faeces, wear gloves when cleaning the litter tray and wash your hands thoroughly afterwards. Follow your vet's advice, particularly if children, pregnant people or anyone with a weakened immune system lives in the household.

Signs depend on the parasite. Fleas and mites may cause itching, hair loss or irritated skin, while intestinal worms can cause diarrhoea, vomiting, weight loss or lethargy. Paralysis ticks may cause weakness, wobbliness, breathing difficulty or a change in your cat's meow.

Contact a vet promptly if you notice these signs. Weakness, breathing difficulty or other possible signs of tick paralysis require urgent veterinary care.

Yes. Cats can develop flea tapeworms after swallowing an infected flea, usually while grooming. Flea control and a worming product that covers flea tapeworms may both be needed to break the cycle.

Never use a dog parasite product on a cat unless the label specifically says it is suitable for cats or your vet has directed you to use it. Some dog products contain ingredients, including permethrin, that are highly toxic to cats.

About the Author

Bec Cat 2
Rebecca Daly BVScVeterinarian & Content Writer

After graduating with a Bachelor of Veterinary Science from the University of Queensland in 2017, Rebecca spent two years working as an equine veterinarian in New Zealand. Upon returning to Australia, she completed a Bachelor of Communications from UQ in 2023. Rebecca is passionate about educating pet parents so they can provide the best lives for their pets. She is the pet parent of a cat named Edith, a domestic short hair adopted from a Petbarn Adoption Centre.